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Evaluation of in vivo biological activities of tetrapyrrole ethanolamides as novel anticancer agents

Paper ID Volume ID Publish Year Pages File Format Full-Text
30994 44524 2010 7 PDF Available
Title
Evaluation of in vivo biological activities of tetrapyrrole ethanolamides as novel anticancer agents
Abstract

The tetrapyrrole ethanolamide derivatives, hematoporphyrin propylether ethanolamide (HPPEEA, 1) and pheophorbide a ethanolamide (PEA, 2) have previously shown some photodynamic activities in an in vitro photodynamic assay (D. Girard et al. Bioorg. Med. Chem. Lett. 18 (2008) 360–365). Extending this study to an in vivo one, HPPEEA and PEA were evaluated for their anticancer, toxicity, and pharmacokinetic activities in mouse animal models. The compounds showed moderate anticancer activity without apparent acute toxicity and without secondary tumour development. This indicates noteworthy anti-metastasis activity. The pharmacokinetic study revealed the compound fast clearances from body tissues. This is an important therapeutic concern since these compounds are light sensitive. Thus, the combination of photodynamic and anti-metastasis activities with fast tissue clearance indicates that HPPEEA and PEA are good candidates for further photodynamic treatment evaluations.

Keywords
Photodynamic therapy; Hematoporphyrin; Pheophorbide ethanolamide; Hematoporphyrin propylether ethanolamide
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Evaluation of in vivo biological activities of tetrapyrrole ethanolamides as novel anticancer agents
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 100, Issue 1, 2 July 2010, Pages 44–50
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
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Price after discount Only $4.95
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Full-text PDF Download
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