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The therapeutic effect of low-level laser on repair of osteochondral defects in rabbit knee

Paper ID Volume ID Publish Year Pages File Format Full-Text
30997 44526 2007 5 PDF Available
Title
The therapeutic effect of low-level laser on repair of osteochondral defects in rabbit knee
Abstract

IntroductionLow level laser therapy (LLLT) has been shown to enhance collagen production and wound healing but its effect on cartilage repair from biomechanical point of view is not known yet. The aim of present study was to evaluate the biomechanical behaviour of repairing osteochondral defect in rabbits which received a pulsed low-level gallium–arsenide (Ga–As) laser irradiation.Materials and methodsOsteochondral defects with 5 mm diameter and 4 mm in depth induced by drilling in right femoral patellar grooves of 41 adolescent male rabbits. They were divided into experimental and control groups. Experimental group received pulsed Ga–As (890 nm) laser irradiation with energy density of 4.8 J/cm2. The rabbits in control group received placebo LLLT with shut-down equipment. The control defects were allowed to heal spontaneously. Each group were divided into three subgroups: A, B and C. Subgroups A, B and C were sacrificed on 4, 8, and 16 weeks after surgery. The knee joint were removed, and the defects were examined biomechanically by in situ-indentation method. The thickness, instantaneous and equilibrium indentation stiffness was measured during the test. Data were analysed using ANOVA and independent sample t-test.ResultWhile no difference was observed in the repaired cartilage biomechanical properties among 4th, 8th, 16th weeks in study groups. The equilibrium indentation stiffness of experimental group was significantly higher in 8th week in comparison with control group.ConclusionLLLT significantly enhances the stiffness of repairing tissue in the 8th week post injury in osteochondral defects in rabbits.

Keywords
Low level laser therapy; Osteochondral defects; Indentation method; Rabbit
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The therapeutic effect of low-level laser on repair of osteochondral defects in rabbit knee
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 88, Issue 1, 27 July 2007, Pages 11–15
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us