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Study of germ tube formation by Candida albicans after photodynamic antimicrobial chemotherapy (PACT)

Paper ID Volume ID Publish Year Pages File Format Full-Text
30998 44526 2007 5 PDF Available
Title
Study of germ tube formation by Candida albicans after photodynamic antimicrobial chemotherapy (PACT)
Abstract

Due to the augmented number of immunocompromised patients, the infections associated to the pathogen of the genus Candida have increased dramatically in the recent years. In order to proliferate, Candida albicans can produce a germ tube formation extending from the cells. The germ tube formation is a transition state from budding to hyphal cells, and represents an essential stage for virulence. In this work we studied the effect of the photodynamic antimicrobial chemotherapy (PACT), a potential antimicrobial treatment on the germ tube formation by C. albicans. Germ tube formation was induced by goat serum after different treatments with Methylene blue (MB) and Laser (683 nm). Our results demonstrated that photodynamic therapy using MB, as a photosensitizing drug; inhibits both the growth and the germ tube formation by C. albicans. Thus, our results suggest the possibility that Methylene blue, combined with light in a specific wavelength, can be used as a promising novel antifungal agent.

Keywords
Photodynamic therapy; Candida albicans; Methylene blue; Germ tube formation; Laser
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Study of germ tube formation by Candida albicans after photodynamic antimicrobial chemotherapy (PACT)
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 88, Issue 1, 27 July 2007, Pages 16–20
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us