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Microfluidic bio-particle manipulation for biotechnology

Paper ID Volume ID Publish Year Pages File Format Full-Text
3100 150 2014 20 PDF Available
Title
Microfluidic bio-particle manipulation for biotechnology
Abstract

•Different bio-particle manipulation techniques for microfluidics have been reviewed.•Different aspects of the methods have been compared.•CNC-machining is discussed briefly for an alternative fabrication process.•Challenges and future research directions are addressed.

Microfluidics and lab-on-a-chip technology offers unique advantages for the next generation devices for diagnostic therapeutic applications. For chemical, biological and biomedical analysis in microfluidic systems, there are some fundamental operations such as separation, focusing, filtering, concentration, trapping, detection, sorting, counting, washing, lysis of bio-particles, and PCR-like reactions. The combination of these operations led to the complete analysis systems for specific applications. Manipulation of the bio-particles is the key ingredient for these applications. Therefore, microfluidic bio-particle manipulation has attracted a significant attention from the academic community. Considering the size of the bio-particles and the throughput of the practical applications, manipulation of the bio-particles is a challenging problem. Different techniques are available for the manipulation of bio-particles in microfluidic systems. In this review, some of the techniques for the manipulation of bio-particles; namely hydrodynamic based, electrokinetic-based, acoustic-based, magnetic-based and optical-based methods have been discussed. The comparison of different techniques and the recent applications regarding the microfluidic bio-particle manipulation for different biotechnology applications are presented. Finally, challenges and the future research directions for microfluidic bio-particle manipulation are addressed.

Keywords
Biomedical; Bioprocess design; Bioseparations; Fluid mechanics; Microfluidics; Bio-particle manipulation
First Page Preview
Microfluidic bio-particle manipulation for biotechnology
Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 92, 15 November 2014, Pages 63–82
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering