fulltext.study @t Gmail

Study on the Interaction between the chiral drug of propranolol and α1-acid glycoprotein by fluorescence spectrophotometry

Paper ID Volume ID Publish Year Pages File Format Full-Text
31034 44532 2007 6 PDF Available
Title
Study on the Interaction between the chiral drug of propranolol and α1-acid glycoprotein by fluorescence spectrophotometry
Abstract

The interaction between the chiral drug of propranolol (PPL) and α1-acid glycoprotein (AGP, orosomucoid) has been first studied by fluorescence spectrophotometry. The fluorescence intensity of PPL increased due to the addition of AGP into PPL. The equation of Scatchard was employed to calculate the association constant and binding site number of the two enantiomers with AGP. The association constant is 2.62 × 105 M−1 for R-PPL and 8.57 × 105 M−1 for S-PPL and the binding site number is 0.41 for R-PPL and 1.17 for S-PPL at 17 °C respectively. The method of thermodynamics was applied to determine the binding type of S-PPL with AGP. The results suggested that the binding type is mainly van der waals force or hydrogen bond. At last the effect of three metal cations on the association constant and the binding site number of S-PPL with AGP was examined.

Keywords
Propranolol; α1-acid glycoprotein; Chiral drug; Fluorescence spectrophotometry; Interaction
First Page Preview
Study on the Interaction between the chiral drug of propranolol and α1-acid glycoprotein by fluorescence spectrophotometry
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 86, Issue 3, 1 March 2007, Pages 246–251
Authors
, , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us