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EPR study of copper(II) complexes of hydroxysalen derivatives in order to be used in the DNA cleavage

Paper ID Volume ID Publish Year Pages File Format Full-Text
31037 44532 2007 7 PDF Available
Title
EPR study of copper(II) complexes of hydroxysalen derivatives in order to be used in the DNA cleavage
Abstract

Two series of functionalised hydroxy-salen-copper(II) complexes with various side chain lengths have been synthesized. The first one is characterised by amino side chain protected by the tert-butyloxycarbonyl group (Boc) whereas, the second series is obtained by removal of the Boc-protecting group under acidic conditions and formation instead of it an ammonium salt. EPR studies were carried out on the copper(II) complexes. EPR signals attributed to monomers and dimers of Cu2+ species were evidenced. Determination of the copper(II) environment in each complex was attempted using all the experimental results. Square planar and tetrahedral symmetries were found for the copper(II) monomers. From the fine structure observed for the pair signal, the distance between the Cu2+ ions in the pair has been calculated (3.9–4.3 Å). From these values, it seems that the formation of pairs is obtained by a face-to-face bimolecular association.

Keywords
EPR; Hydroxy-salen-copper(II) complexes; Monomers; Dimers; DNA cleavage
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 86, Issue 3, 1 March 2007, Pages 272–278
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us