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New insights to primary photodynamic effects – Singlet oxygen kinetics in living cells

Paper ID Volume ID Publish Year Pages File Format Full-Text
31050 44534 2010 7 PDF Available
Title
New insights to primary photodynamic effects – Singlet oxygen kinetics in living cells
Abstract

The kinetics of chemical singlet oxygen quencher consumption inside living cells during low dose illumination was revealed via time resolved singlet oxygen luminescence detection. Deviations of the measured data from the common theoretical model for 1O2 kinetics forced the authors to consider a one-dimensional diffusion model for description of the kinetics of singlet oxygen generated by membrane localized photosensitizers. Our observations reconcile seemingly contradictory reports presenting different values for the efficiency of singlet oxygen interaction with cells.

Keywords
Singlet oxygen; Photodynamic therapy; Photosensitization; Quencher; Phototoxicity; Time correlated multi photon counting
First Page Preview
New insights to primary photodynamic effects – Singlet oxygen kinetics in living cells
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 98, Issue 3, 8 March 2010, Pages 173–179
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering