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(EZ)-Cyclobilirubin formation from bilirubin in complex with serum albumin derived from various species

Paper ID Volume ID Publish Year Pages File Format Full-Text
31087 44539 2010 6 PDF Available
Title
(EZ)-Cyclobilirubin formation from bilirubin in complex with serum albumin derived from various species
Abstract

We determined the specificity of photochemical changes of bilirubin in complex with serum albumin from various species. There were no general trends in the configurational photoisomerizations of (ZE)-bilirubin/(ZZ)-bilirubin and (EZ)-bilirubin/(ZZ)-bilirubin associated with the albumins from various species as compared to those associated with human serum albumin. The absorbance spectra of bilirubin in complex with albumins from various species differed, indicating that the three-dimensional structures of (ZZ)-bilirubin bound to the various serum albumins, which are substrates of (ZE)- and (EZ)-bilirubin, differ among species. The rates of conversion of the (EZ)-bilirubin isomer into the structural cyclobilirubin isomer were similar for the albumins of chicken, rat, rabbit, dog, bovine, and pig, and were significantly slower than the rate for human serum albumin. This suggests that the three-domain human albumin has evolved to allow ready conversion of (EZ)-bilirubin to (EZ)-cyclobilirubin. Cyclobilirubin formation in a bilirubin-alpha-fetoprotein solution was much lower than that in a bilirubin–human serum albumin solution. It is believed that the ability of human serum albumin to facilitate the photochemical change of bilirubin was evolutionarily selected in response to neonatal jaundice in humans.

Keywords
Configurational photoisomerization; Photochemical change; Human serum albumin; Structural photoisomerization; Various species
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(EZ)-Cyclobilirubin formation from bilirubin in complex with serum albumin derived from various species
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 98, Issue 2, 12 February 2010, Pages 138–143
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us