fulltext.study @t Gmail

Studies on curcumin and curcuminoids. XXXIV. Photophysical properties of a symmetrical, non-substituted curcumin analogue

Paper ID Volume ID Publish Year Pages File Format Full-Text
31104 44544 2009 10 PDF Available
Title
Studies on curcumin and curcuminoids. XXXIV. Photophysical properties of a symmetrical, non-substituted curcumin analogue
Abstract

Curcumin is the main constituent of curry. In its ground state it shows chemo-preventive, chemo-therapeutic, anti-inflammatory and immune stimulating effects, and it is considered as a drug or drug model in the treatment of AIDS and cystic fibrosis. Further biological activity is induced in curcumin by light exposure: cytotoxicity is enhanced and photosensitized antibacterial effects are achieved. For the curcumin cis enol conformer, the fastest deactivation mechanism of the first excited singlet state is an excited-state intra-molecular proton transfer, which brings curcumin back to the ground state. This mechanism, as well as reketonization, interaction with the solvent and photodegradation, compete with the phototherapeutic action. The native compound curcumin carries phenolic hydroxyl and methoxy groups that influence the molecular charge distribution and hence the excited-state intra-molecular proton transfer rate in an unpredictable way. In this work we study static and time-resolved spectroscopic properties of a non-substituted curcuminoid that lacks both the phenolic hydroxyl and the phenolic methoxy groups. The photophysical properties of this compound are compared to those of native curcumin, in order to provide a rationale to the design of curcuminoids with molecular structures optimized for a photosensitizer.

Keywords
Curcumin; Photosensitizer; Excited state lifetime; Excited-state intra-molecular proton transfer; Fluorescence decay
First Page Preview
Studies on curcumin and curcuminoids. XXXIV. Photophysical properties of a symmetrical, non-substituted curcumin analogue
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 97, Issue 2, 9 November 2009, Pages 77–86
Authors
, , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us