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Specific interaction of jacalin with phycocyanin, a fluorescent phycobiliprotein

Paper ID Volume ID Publish Year Pages File Format Full-Text
31105 44544 2009 7 PDF Available
Title
Specific interaction of jacalin with phycocyanin, a fluorescent phycobiliprotein
Abstract

Recent research has shown that, like porphyrins, phycocyanin (PC) too can produce singlet oxygen upon excitation with the appropriate radiation and hence could be useful in photodynamic therapy (PDT) for cancer. Unlike porphyrins, PC has the advantage of being a non-toxic, non-carcinogenic, soluble protein. However, the challenge would be to target the fluorescent phycobiliprotein to malignant cells. We report here that the tumor-specific lectin, jacalin, binds PC specifically in a carbohydrate-independent manner and with affinities better than that for porphyrins. Hence the lectin could prove to be a useful carrier for targeted delivery of PC. The interaction involves both ionic and hydrophobic interactions and more than one contact site.

Keywords
Protein–protein interaction; Jacalin; Phycocyanin; Photodynamic therapy
First Page Preview
Specific interaction of jacalin with phycocyanin, a fluorescent phycobiliprotein
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 97, Issue 2, 9 November 2009, Pages 87–93
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering