fulltext.study @t Gmail

In vitro model of vitamin D3 (Cholecalciferol) synthesis by UV radiation: Dose–response relationships

Paper ID Volume ID Publish Year Pages File Format Full-Text
31124 44549 2008 6 PDF Available
Title
In vitro model of vitamin D3 (Cholecalciferol) synthesis by UV radiation: Dose–response relationships
Abstract

Vitamin D deficiency is a major health concern worldwide. Very little is understood regarding its production in the human body by exposure to UV radiation. In particular, we have no means of predicting how much vitamin D (cholecalciferol) will be produced in the skin after exposure to sunlight. Using a refined in vitro model, we found that there is a nonlinear relationship between UV dose and cholecalciferol synthesis. Two minimal erythemal doses (MED) of UV radiation produced 1.84 μg/mL of cholecalciferol whereas 4 MED produced 2.81 μg/mL. We also found that the production of cholecalciferol is restricted by the initial concentration of its precursor (7-dehydrocholesterol, 7-DHC). For example, using an initial concentration of 7-DHC of 102 μg/mL, the resultant cholecalciferol production was 1.05 μg/mL after receiving 4 MED exposure. Under the same exposure conditions, an initial concentration of 305 μg/mL yielded 2.81 g/mL of cholecalciferol. The data presented in this paper has important implications for humans, including: (1) increasing UV exposure does not result in a proportionate increase in the amount of cholecalciferol that is produced; and (2) the initial concentration of 7-DHC in the skin may impact the amount of cholecalciferol that can be synthesized. When translating these results to population groups, we will discuss how the sun exposure message needs to be carefully formulated to account for such considerations.

Keywords
Vitamin D; Ultraviolet; UV; Sun; Skin cancer
First Page Preview
In vitro model of vitamin D3 (Cholecalciferol) synthesis by UV radiation: Dose–response relationships
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 93, Issue 2, 13 November 2008, Pages 88–93
Authors
, , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us