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A theoretical study on the quenching mechanisms of triplet state riboflavin by tryptophan and tyrosine

Paper ID Volume ID Publish Year Pages File Format Full-Text
31129 44552 2008 3 PDF Available
Title
A theoretical study on the quenching mechanisms of triplet state riboflavin by tryptophan and tyrosine
Abstract

The reactions of tryptophan (Trp) and tyrosine (Tyr) with endogenous photosensitizer riboflavin (RF) have gained much interest for their crucial roles in various photobiological processes. In this paper, the quenching mechanisms of triplet state RF by Trp and Tyr have been explored employing density functional theory calculations. It is revealed that the H-atom transfer reaction from Trp and Tyr to triplet state RF is more favorable on thermodynamic grounds compared with direct energy transfer or direct electron transfer pathways. During the photosensitization, RF can photogenerate various reactive oxygen species (ROS) as intermediates, while the present study provides some deeper insights into the photosensitizing behaviors of triplet state RF by reacting directly with Trp and Tyr.

Keywords
Riboflavin; Tryptophan; Tyrosine; Triplet state; Quenching mechanism; Density functional theory
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A theoretical study on the quenching mechanisms of triplet state riboflavin by tryptophan and tyrosine
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 92, Issue 1, 24 July 2008, Pages 10–12
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us