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Fermentation process for continuous production of succinic acid in a fibrous bed bioreactor

Paper ID Volume ID Publish Year Pages File Format Full-Text
3116 151 2014 7 PDF Available
Title
Fermentation process for continuous production of succinic acid in a fibrous bed bioreactor
Abstract

•Continuous succinic acid production using FBB by Actinobacillus succinogenes is first reported.•Succinic acid concentration 55.3 g/L, productivity 2.77 g/L/h and yield 0.8 g/g were achieved with operation time over 18 days.•Kinetic equation showed that succinic acid 60 g/L might be a critical inhibition concentration.

Succinic acid (SA) was produced from Actinobacillus succinogenes with high cell density by continuous fermentation using fibrous bed bioreactor (FBB). The effects of feeding glucose concentration, dilution rate, and pH on continuous production of SA were examined to achieve an efficient and economical bioprocess. The optimum feeding glucose concentration, dilution rate, and pH were 80 g/L, 0.05 1/h, and 6.0–6.5, respectively. A SA concentration of 55.3 ± 0.8 g/L, productivity of 2.77 ± 0.04 g/L/h, and yield of 0.8 ± 0.02 g/g were obtained, and the continuous fermentation exhibited long-term stability for as long as 18 days (440 h) with no obvious fluctuations in both SA and biomass levels. The Jerusalimsky equation for the specific rate of SA production presented the inhibition phenomenon of the product, demonstrating that 60 g/L SA might be a critical concentration in this continuous FBB system. The results obtained could be beneficial for future fermentor designs and improvements in SA production.

Keywords
Actinobacillus succinogenes; Succinic acid; Bioprocess design; Bioreactors; Fermentation; Immobilized cells
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Fermentation process for continuous production of succinic acid in a fibrous bed bioreactor
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 91, 15 October 2014, Pages 92–98
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us