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Effects of a single near-infrared laser treatment on cutaneous wound healing: Biometrical and histological study in rats

Paper ID Volume ID Publish Year Pages File Format Full-Text
31172 44561 2007 9 PDF Available
Title
Effects of a single near-infrared laser treatment on cutaneous wound healing: Biometrical and histological study in rats
Abstract

BackgroundLow intensity laser therapy has been recommended to support the cutaneous repair; however, so far studies do not have evaluated the tissue response following a single laser treatment. This study investigated the effect of a single laser irradiation on the healing of full-thickness skin lesions in rats.MethodsForty-eight male rats were randomly divided into three groups. One surgical lesion was created on the back of rats using a punch of 8 mm in diameter. One group was not submitted to any treatment after surgery and it was used as control. Two energy doses from an 830-nm near-infrared diode laser were used immediately post-wounding: 1.3 J cm−2 and 3 J cm−2. The laser intensity 53 mW cm−2 was kept for both groups. Biometrical and histological analyses were accomplished at days 3, 7 and 14 post-wounding.ResultsIrradiated lesions presented a more advanced healing process than control group. The dose of 1.3 J cm−2 leaded to better results. Lesions of the group irradiated with 1.3 J cm−2 presented faster lesion contraction showing quicker re-epithelization and reformed connective tissue with more organized collagen fibers.ConclusionsLow-intensity laser therapy may accelerate cutaneous wound healing in a rat model even if a single laser treatment is performed. This finding might broaden current treatment regimens.

Keywords
GaAlAs diode laser; Full-thickness cutaneous defects; Laser biomodulation; Low intensity laser therapy; Skin repair
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Effects of a single near-infrared laser treatment on cutaneous wound healing: Biometrical and histological study in rats
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 87, Issue 3, 26 June 2007, Pages 145–153
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us