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Phototoxicity of a core-modified porphyrin and induction of apoptosis

Paper ID Volume ID Publish Year Pages File Format Full-Text
31184 44564 2006 8 PDF Available
Title
Phototoxicity of a core-modified porphyrin and induction of apoptosis
Abstract

A core-modified porphyrin, 5-phenyl-10,15-bis(carboxylatomethoxyphenyl)-20-(2-thienyl)-21,23-dithiaporphyrin (IY69) was studied in vitro for photodynamic activity under a variety of experimental protocols. Variables included the cell line (the rodent mammary tumor cell line R3230AC or the human breast cancer cell line MCF-7), light fluence, time of exposure of the cell cultures to IY69, and the time post-irradiation for cell counting. The length of time cell cultures were exposed to IY69 impacted cellular accumulation and cellular localization, phototoxicity, and the apparent mode of cell death – apoptosis vs. necrosis.

Keywords
Core-modified porphyrin; Breast cancer; Photodynamic therapy; Apoptosis
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 85, Issue 3, 1 December 2006, Pages 155–162
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
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