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Photophysics of norharmane in solution phase: From homogeneous to microheterogeneous environments

Paper ID Volume ID Publish Year Pages File Format Full-Text
31338 44744 2010 11 PDF Available
Title
Photophysics of norharmane in solution phase: From homogeneous to microheterogeneous environments
Abstract

The photobehavior of norharmane (9H-pyrido[3,4-b]-indole) (NHM), one of the vastly used skeleton of drugs in therapeutic applications, has recently been the subject of increasing interest due to the finding of their phototoxic and photocarcinogenic properties. Its absorption and fluorescence behavior from different prototropic species show remarkable sensitivity towards the polarity, viscosity and local pH, exhibited by various microheterogeneous bio and biomimetic environments like micelles, reverse micelles, proteins, etc. The significant results obtained for NHM in homogeneous and a series of microheterogeneous environments is reviewed in this account. Much attention has been given to the properties of the excited states, location and biodistribution of NHM in different biological environments. The results can help in understanding the photophysics of the probe in biological environments and in assessing the correlation between different prototropic forms and biological activity.

Keywords
Norharmane; Proton transfer; Photophysics; Micelle; Cyclodextrin; Serum albumin
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Photophysics of norharmane in solution phase: From homogeneous to microheterogeneous environments
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology C: Photochemistry Reviews - Volume 11, Issues 2–3, September 2010, Pages 62–72
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
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