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Photoinduced processes in naproxen-based chiral dyads

Paper ID Volume ID Publish Year Pages File Format Full-Text
31384 44754 2007 15 PDF Available
Title
Photoinduced processes in naproxen-based chiral dyads
Abstract

Naproxen [(+)-(S)- or (−)-(R)-2-(6-methoxynaphthalen-2-yl)propanoic acid, NPX] is a photoactive naphthalene derivative, widely prescribed as nonsteroidal anti-inflammatory drug. A variety of NPX-derived dyads have been synthesized, and their photobehavior has been investigated. In addition to the NPX unit, these dyads contain different types of photo- and/or electroactive moieties, such as naphthalenes (NAP), diaryl ketones (KPF), tertiary amines (PYR), oxetanes (OXT) or thymidine (THY). The excited state intramolecular interactions occurring in the dyads have been examined by both steady-state and time-resolved techniques. As a general observation, dynamic quenching of the NPX singlet-excited state is observed, as indicated by the reduced lifetimes in comparison to the isolated NPX chromophore. This is the result of energy transfer (NPX–NAP, NPX–KPF), electron transfer (NPX–PYR, NPX–OXT), excimer (NPX–NPX) or exciplex (NPX–NAP, NPX–KPF) formation, radiationless decay (NPX–THY), and/or chemical reaction (NPX–OXT, NPX–THY). Thus, the discussed dyads constitute interesting case studies for the photophysical behavior of naproxen in various mechanistic scenarios. For the dyads synthesized as diastereomeric pairs, a significant stereodifferentiation in the photophysical/photochemical properties is observed. Due to the delicate balance between the competing excited state deactivation pathways and the multiple signaling possibilities, these dyads can also be used as probes for the study of specific microenvironments of biological interest.

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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology C: Photochemistry Reviews - Volume 8, Issue 3, November 2007, Pages 128–142
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
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