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Metabolic engineering strategies for microbial synthesis of oleochemicals

Paper ID Volume ID Publish Year Pages File Format Full-Text
31506 44807 2015 11 PDF Available
Title
Metabolic engineering strategies for microbial synthesis of oleochemicals
Abstract

•Oleochemicals are attractive molecules that can be produced via metabolic engineering.•Review of fatty acid metabolism and oleochemical producing enzymes.•Review of successful metabolic engineering strategies in bacteria and yeast.•Commentary on remaining challenges to commercialization.

Microbial synthesis of oleochemicals has advanced significantly in the last decade. Microbes have been engineered to convert renewable substrates to a wide range of molecules that are ordinarily made from plant oils. This approach is attractive because it can reduce a motivation for converting tropical rainforest into farmland while simultaneously enabling access to molecules that are currently expensive to produce from oil crops. In the last decade, enzymes responsible for producing oleochemicals in nature have been identified, strategies to circumvent native regulation have been developed, and high yielding strains have been designed, built, and successfully demonstrated. This review will describe the metabolic pathways that lead to the diverse molecular features found in natural oleochemicals, highlight successful metabolic engineering strategies, and comment on areas where future work could further advance the field.

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Keywords
Mt, Metric ton; CoA, Coenzyme A; 2-MP-CoA, 2-methyl-propionyl-CoA; 3-MB-CoA, 3-methyl-butyryl-CoA; 2-MB-CoA, 2-methyl-butyrl-CoA; ACCase, Acetyl-CoA carboxylase; FFA, Free fatty acid; FAEE, Fatty acid ethyl ester; FAME, Fatty acid methyl ester; AAce, Acet
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Publisher
Database: Elsevier - ScienceDirect
Journal: Metabolic Engineering - Volume 29, May 2015, Pages 1–11
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us