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Establishing a platform cell factory through engineering of yeast acetyl-CoA metabolism

Paper ID Volume ID Publish Year Pages File Format Full-Text
31648 44827 2013 7 PDF Available
Title
Establishing a platform cell factory through engineering of yeast acetyl-CoA metabolism
Abstract

Production of fuels and chemicals by industrial biotechnology requires efficient, safe and flexible cell factory platforms that can be used for production of a wide range of compounds. Here we developed a platform yeast cell factory for efficient provision of acetyl-CoA that serves as precursor metabolite for a wide range of industrially interesting products. We demonstrate that the platform cell factory can be used to improve the production of α-santalene, a plant sesquiterpene that can be used as a perfume by four-fold. This strain would be a useful tool to produce a wide range of acetyl-CoA-derived products.

► Engineering of the yeast central carbon metabolism to develop a platform cell factory. ► More efficient provision of the precursor metabolite acetyl-CoA. ► The platform cell factory can be used for improving α-santalene production by four-fold.

Keywords
Acetyl-CoA; Cell factory; Saccharomyces cerevisiae; α-Santalene
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Establishing a platform cell factory through engineering of yeast acetyl-CoA metabolism
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Publisher
Database: Elsevier - ScienceDirect
Journal: Metabolic Engineering - Volume 15, January 2013, Pages 48–54
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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