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Hybrid antibiotics with the nikkomycin nucleoside and polyoxin peptidyl moieties

Paper ID Volume ID Publish Year Pages File Format Full-Text
31676 44828 2011 9 PDF Available
Title
Hybrid antibiotics with the nikkomycin nucleoside and polyoxin peptidyl moieties
Abstract

Acting as competitive inhibitors of chitin synthase, nikkomycins and polyoxins are potent antibiotics against pathogenic fungi. Taking advantage of the structural similarities between these two peptidyl nucleoside antibiotics, genes required for the biosynthesis of the dipeptidyl moiety of polyoxin from Streptomyces cacaoi were introduced into a Streptomyces ansochromogenes mutant producing the nucleoside moiety of nikkomycin X. Two hybrid antibiotics were generated. One of them was identified as polyoxin N, and the other, a novel compound, was named polynik A. The hybrid antibiotics exhibited merits from both parents: they had better inhibitory activity against phytopathogenic fungi than polyoxin B, and were more stable under different pH and temperature conditions than nikkomycin X. This study demonstrates the use of the combinatorial biosynthetic approach to produce valuable and novel hybrid antibiotics with improved properties.

Keywords
Combinatorial biosynthesis; Nikkomycin; Polyoxin; Hybrid antibiotics
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Hybrid antibiotics with the nikkomycin nucleoside and polyoxin peptidyl moieties
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Publisher
Database: Elsevier - ScienceDirect
Journal: Metabolic Engineering - Volume 13, Issue 3, May 2011, Pages 336–344
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us