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Smart medication through combination of synthetic biology and cell microencapsulation

Paper ID Volume ID Publish Year Pages File Format Full-Text
31697 44830 2012 9 PDF Available
Title
Smart medication through combination of synthetic biology and cell microencapsulation
Abstract

Recent advances in the field of synthetic biology have led to the design of a new generation of complex, man-made biological networks that operate inside living cells in a desired manner. Key elements of these systems are often controllable genetic switches that are capable of processing therapeutic signals by sensing and responding to the environment. For biomedical applications, however, it is necessary to seal these engineered cells in order to protect them from the host immune system and enable straightforward removal after completion of the therapy. A promising and successful approach is the microencapsulation of defined cells into a semi-permeable and biocompatible microcapsule. Shielding from the external environment still allows exchange to occur on a molecular basis. Thus, the powerful combination of synthetic biology and microencapsulation has been opening the door to novel and innovative cell-based biomedical applications, such as smart implantable drug delivery systems. This review highlights recent developments in the overlap of these two areas, thereby presenting promising developments and perspectives for future treatment strategies.

► Cell implants are allogenic or xenogenic cells enclosed by a semi-permeable membrane. ► Enclosing membrane allows nutrition supply but prevents fast immunogenic response. ► Synthetic biology offers versatile toolbox for engineering tailor-made implantable cells. ► Recent advances show cell implants capable of precisely treating defined diseases.

Keywords
Synthetic Biology; Cell Implants; Encapsulation; Synthetic Gene Networks
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Smart medication through combination of synthetic biology and cell microencapsulation
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Publisher
Database: Elsevier - ScienceDirect
Journal: Metabolic Engineering - Volume 14, Issue 3, May 2012, Pages 252–260
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us