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Mathematical optimization applications in metabolic networks

Paper ID Volume ID Publish Year Pages File Format Full-Text
31718 44832 2012 15 PDF Available
Title
Mathematical optimization applications in metabolic networks
Abstract

Genome-scale metabolic models are increasingly becoming available for a variety of microorganisms. This has spurred the development of a wide array of computational tools, and in particular, mathematical optimization approaches, to assist in fundamental metabolic network analyses and redesign efforts. This review highlights a number of optimization-based frameworks developed towards addressing challenges in the analysis and engineering of metabolic networks. In particular, three major types of studies are covered here including exploring model predictions, correction and improvement of models of metabolism, and redesign of metabolic networks for the targeted overproduction of a desired compound. Overall, the methods reviewed in this paper highlight the diversity of queries, breadth of questions and complexity of redesigns that are amenable to mathematical optimization strategies.

► Review of mathematical optimization applications in metabolic network analysis. ► Optimization techniques to explore model predictions. ► Optimization techniques to correct and improve models of metabolism. ► Optimization techniques to redesign metabolic networks for overproduction.

Keywords
Mathematical optimization; Metabolic model; Metabolic network analysis; Metabolic network redesign
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Publisher
Database: Elsevier - ScienceDirect
Journal: Metabolic Engineering - Volume 14, Issue 6, November 2012, Pages 672–686
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
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