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Metabolic engineering of Escherichia coli for 1-butanol production

Paper ID Volume ID Publish Year Pages File Format Full-Text
31885 44849 2008 7 PDF Available
Title
Metabolic engineering of Escherichia coli for 1-butanol production
Abstract

Compared to ethanol, butanol offers many advantages as a substitute for gasoline because of higher energy content and higher hydrophobicity. Typically, 1-butanol is produced by Clostridium in a mixed-product fermentation. To facilitate strain improvement for specificity and productivity, we engineered a synthetic pathway in Escherichia coli and demonstrated the production of 1-butanol from this non-native user-friendly host. Alternative genes and competing pathway deletions were evaluated for 1-butanol production. Results show promise for using E. coli for 1-butanol production.

Keywords
Biofuel; Butanol; E. coli
First Page Preview
Metabolic engineering of Escherichia coli for 1-butanol production
Publisher
Database: Elsevier - ScienceDirect
Journal: Metabolic Engineering - Volume 10, Issue 6, November 2008, Pages 305–311
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering