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Steady-state analysis of metabolic pathways: Comparing the double modulation method and the lin–log approach

Paper ID Volume ID Publish Year Pages File Format Full-Text
31941 44857 2007 9 PDF Available
Title
Steady-state analysis of metabolic pathways: Comparing the double modulation method and the lin–log approach
Abstract

The increasing interest in studying enzyme kinetics under in vivo conditions requires practical methods to estimate control parameters from experimental data. In contrast to currently established approaches of dynamic modelling, this paper addresses the steady-state analysis of metabolic pathways. Within the framework of metabolic control analysis (MCA), elasticity coefficients are used to describe the control properties of a local enzyme reaction. The double modulation method is one of the first experimental approaches to estimate elasticity coefficients from measurements of steady-state flux rates and metabolite concentrations. We propose a generalized form of the double modulation method and compare it to the recently developed linear–logarithmic approach.

Keywords
Metabolic control analysis; Double modulation method; Lin–log approach; Parameter estimation
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Publisher
Database: Elsevier - ScienceDirect
Journal: Metabolic Engineering - Volume 9, Issues 5–6, September–November 2007, Pages 433–441
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us