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Development of a metabolic network design and optimization framework incorporating implementation constraints: A succinate production case study

Paper ID Volume ID Publish Year Pages File Format Full-Text
32008 44875 2006 12 PDF Available
Title
Development of a metabolic network design and optimization framework incorporating implementation constraints: A succinate production case study
Abstract

We have developed a pathway design and optimization scheme that accommodates genetically and/or environmentally derived operational constraints. We express the full set of theoretically optimal pathways in terms of the underlying elementary flux modes and then examine the sensitivity of the optimal yield to a wide class of physiological perturbations. Though the scheme is general it is best appreciated in a concrete context: we here take succinate production as our model system. The scheme produces novel pathway designs and leads to the construction of optimal succinate production pathway networks. The model predictions compare very favorably with experimental observations.

Keywords
Pathway design and optimization; Elementary flux mode; Sensitivity; Operational constraints; Escherichia coli; Succinate production
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Development of a metabolic network design and optimization framework incorporating implementation constraints: A succinate production case study
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Publisher
Database: Elsevier - ScienceDirect
Journal: Metabolic Engineering - Volume 8, Issue 1, January 2006, Pages 46–57
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us