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Zwitterionic polymer-protein conjugates reduce polymer-specific antibody response

Paper ID Volume ID Publish Year Pages File Format Full-Text
32019 44890 2016 7 PDF Available
Title
Zwitterionic polymer-protein conjugates reduce polymer-specific antibody response
Abstract

•A zwitterionic polymer-protein conjugate does not elicit polymer-specific antibodies.•It alleviates anti-drug antibodies.•It improves upon the pharmacokinetics of native and polyethylene glycol conjugates.

SummaryProteins are promising therapeutics with several design challenges, such as their inherent immunogenicity due to their exogenous source or short circulation time. The common solution to such issues is the chemical conjugation of the amphiphilic polymer poly(ethylene glycol) (PEG), a process known as PEGylation. However, several studies demonstrated a decrease in protein bioactivity or an increase in the presence of specific antibodies post PEGylation, highlighting the importance of an alternative strategy. Here we compare the performance of a superhydrophilic zwitterionic polymer in protecting an immunogenic protein to PEG in (i) the maintenance of enzyme activity and stability post modification, (ii) mitigation of the antibody response elicited by the polymer and any subsequent effect on pharmacokinetics, and (iii) minimization of host response toward the underlying protein. In contrast to PEG, zwitterionic conjugation decreases host antibody response without sacrificing bioactivity or generating polymer-specific antibodies.

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Keywords
Zwitterionic materials; Polymer-drug conjugates; Anti-drug antibodies
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Zwitterionic polymer-protein conjugates reduce polymer-specific antibody response
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 11, Issue 3, June 2016, Pages 285–291
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us