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Two-dimensional non-carbonaceous materials-enabled efficient photothermal cancer therapy

Paper ID Volume ID Publish Year Pages File Format Full-Text
32020 44890 2016 17 PDF Available
Title
Two-dimensional non-carbonaceous materials-enabled efficient photothermal cancer therapy
Abstract

•Overview of 2D non-carbonaceous material family, their synthetic methods and multifunctionalization for PTT.•Summary of 2D non-carbonaceous materials for efficient PTT against cancers.•Summary of the biological effects and biosafety of 2D non-carbonaceous materials for PTT applications.•Discussion of the unsolved critical issues/challenges and research directions of 2D nano-carbonaceous materials for PTT.

Based on the unique two-dimensional (2D) planar nanostructure with atomic-thin thickness, abundant composition variations and the corresponding exceptional physiochemical/biological performances, the emerging inorganic 2D nanomaterials with high biocompatibility have been becoming one of the most promising material nanosystems of great potentials for applications in biomedicine. This review focuses on the unique photothermal-conversion property of several new representative 2D nanomaterials beyond graphene for photothermal conversion-based tumor hyperthermia and theranostic biomedicine, including transition metal dichalcogenides (TMDCs, such as MoS2, WS2, TiS2 and Bi2Se3), black phosphorous (P), metal Pd nanosheets and their composite nanosheets. Based on high photothermal-conversion efficiency of these 2D nanomaterials, this review first highlights the design, synthesis and surface functionalization of 2D nanomaterials for photothermal therapy (PTT) ablation of cancer cells/tissues. The representative strategies of functionalizing these 2D nanomaterials for imaging-guided PTT and PTT-based synergistic cancer therapy are then discussed. The preliminary progresses on biosafety evaluation of these 2D nanomaterials were also briefly summarized and discussed. Finally, we discussed the state-of-art unsolved critical issues and challenges, and outlooked further research directions of 2D nanomaterials for potential clinical translation for PTT tumor ablation. It is believed that the fast development and promising performance of these biocompatible 2D materials can provide a highly efficient nanoplatform for combating cancer by hyperthermia.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (402 K)Download as PowerPoint slideBased on the unique two-dimensional (2D) planar nanostructure with atomic-thin thickness, abundant composition variations and the corresponding exceptional physiochemical/biological performances, the emerging inorganic 2D nanomaterials with high biocompatibility have been becoming one of the most promising material nanosystems of great potentials for applications in biomedicine. This review focuses on the unique photothermal-conversion property of several new representative 2D nanomaterials beyond graphene for photothermal conversion-based tumor hyperthermia and theranostic biomedicine, including transition metal dichalcogenides (TMDCs, such as MoS2, WS2, TiS2 and Bi2Se3), black phosphorous (P), metal Pd nanosheets and their composite nanosheets. Based on high photothermal-conversion efficiency of these 2D nanomaterials, this review first highlights the design, synthesis and surface functionalization of 2D nanomaterials for photothermal therapy (PTT) ablation of cancer cells/tissues. The representative strategies of functionalizing these 2D nanomaterials for imaging-guided PTT and PTT-based synergistic cancer therapy are then discussed. The preliminary progresses on biosafety evaluation of these 2D nanomaterials were also briefly summarized and discussed. Finally, we discussed the state-of-art unsolved critical issues and challenges, and outlooked further research directions of 2D nanomaterials for potential clinical translation for PTT tumor ablation. It is believed that the fast development and promising performance of these biocompatible 2D materials can provide a highly efficient nanoplatform for combating cancer by hyperthermia.

Keywords
Two-dimensional materials; Photothermal therapy; nanotechnology; Nanotoxicity; Cancer therapy
First Page Preview
Two-dimensional non-carbonaceous materials-enabled efficient photothermal cancer therapy
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 11, Issue 3, June 2016, Pages 292–308
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering