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Principles of nanoparticle formation by flash nanoprecipitation

Paper ID Volume ID Publish Year Pages File Format Full-Text
32047 44892 2016 16 PDF Available
Title
Principles of nanoparticle formation by flash nanoprecipitation
Abstract

•Flash nanoprecipitation (FNP) is a versatile solute nanoparticle production tool.•FNP provides high solute loadings and encapsulation efficiencies.•Relevant factors in FNP are mixing, supersaturation, and stabilization.•FNP uses include multifunctional nanoparticles for drug delivery and imaging.•Nanoparticles for active targeting are easily produced via FNP.

SummaryRapid precipitation is an efficient approach for engineering materials at the nanoscale. By controlling solute nucleation and growth rates in solvent precipitation processes, the size of the resulting nanoparticles (NP) can be controlled. This review discusses Flash Nanoprecipitation (FNP), a technique developed for NP formation using copolymer stabilization. FNP has been explored for various applications, including NP formulation for drugs and imaging agents. The review highlights mixing considerations, supersaturation requirements, and stabilizer selection to provide controlled size NP via FNP, and includes a summary of current understanding of the FNP process, as well as relevant examples and applications.

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Keywords
Flash nanoprecipitation; Nanoparticle; Supersaturation; Block copolymer; Drug delivery
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 11, Issue 2, April 2016, Pages 212–227
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us