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Electrostatic interactions favor the binding of positive nanoparticles on cells: A reductive theory

Paper ID Volume ID Publish Year Pages File Format Full-Text
32055 44893 2015 4 PDF Available
Title
Electrostatic interactions favor the binding of positive nanoparticles on cells: A reductive theory
Abstract

•Positive nanoparticle/cell membrane interactions are privileged.•It is supposedly due to favorable electrostatic interactions.•But in biological media, a protein corona forms and adds a level of complexity.

It is acknowledged that physico-chemical features of nanoparticles have a major impact on their uptake, and especially their surface charge. A widespread observation is that positively charged nanoparticles are more uptaken by cells than neutral or negatively charged nanoparticles. The reason commonly evoked is the favorable electrostatic interactions with negatively charged cell membrane. However, this explanation seems simplistic as it does not take into account a fundamental element: the nanoparticle protein corona. This adds a new level of complexity in the interactions with biological systems that cannot be any more limited to electrostatic binding.

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Keywords
Nanoparticle; Protein corona; Nanoparticle/cell interactions; Cellular uptake
First Page Preview
Electrostatic interactions favor the binding of positive nanoparticles on cells: A reductive theory
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 10, Issue 6, December 2015, Pages 677–680
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering