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Core-crosslinked polymeric micelles: Principles, preparation, biomedical applications and clinical translation

Paper ID Volume ID Publish Year Pages File Format Full-Text
32083 44898 2015 25 PDF Available
Title
Core-crosslinked polymeric micelles: Principles, preparation, biomedical applications and clinical translation
Abstract

•Polymeric micelles (PM) are promising carrier materials for hydrophobic drugs.•The dynamic nature of PM leads to premature disintegration and drug release.•Covalent core-crosslinking (CC) of PM improves their stability and in vivo performance.•Covalent drug entrapment in CCPM avoids premature release and makes it tailorable.•CCPM with covalently entrapped drugs have shown promising efficacy in animal models.

SummaryPolymeric micelles (PM) are extensively used to improve the delivery of hydrophobic drugs. Many different PM have been designed and evaluated over the years, and some of them have steadily progressed through clinical trials. Increasing evidence suggests, however, that for prolonged circulation times and for efficient EPR-mediated drug targeting to tumors and to sites of inflammation, PM need to be stabilized, to prevent premature disintegration. Core-crosslinking is among the most popular methods to improve the in vivo stability of PM, and a number of core-crosslinked polymeric micelles (CCPM) have demonstrated promising efficacy in animal models. The latter is particularly true for CCPM in which (pro-) drugs are covalently entrapped. This ensures proper drug retention in the micelles during systemic circulation, efficient drug delivery to pathological sites via EPR, and tailorable drug release kinetics at the target site. We here summarize recent advances in the CCPM field, addressing the chemistry involved in preparing them, their in vitro and in vivo performance, potential biomedical applications, and guidelines for efficient clinical translation.

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Keywords
Nanomedicine; Drug targeting; EPR; Micelle; Polymer; Core-crosslinking
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Core-crosslinked polymeric micelles: Principles, preparation, biomedical applications and clinical translation
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 10, Issue 1, February 2015, Pages 93–117
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us