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Anthracycline nano-delivery systems to overcome multiple drug resistance: A comprehensive review

Paper ID Volume ID Publish Year Pages File Format Full-Text
32119 44901 2013 19 PDF Available
Title
Anthracycline nano-delivery systems to overcome multiple drug resistance: A comprehensive review
Abstract

•Most comprehensive review to discuss anthracycline nanoparticles to overcome MDR•Discuss +10 types of developed anthracycline nanoparticles to overcome MDR.•Discuss +10 proposed mechanisms of anthracycline nanoparticles to overcome MDR.•Provide a useful guidance for nanoparticle formulation development to overcome MDR.

SummaryAnthracyclines (doxorubicin, daunorubicin, and idarubicin) are very effective chemotherapeutic drugs to treat many cancers; however, the development of multiple drug resistance (MDR) is one of the major limitations for their clinical applications. Nano-delivery systems have emerged as the novel cancer therapeutics to overcome MDR. Up until now, many anthracycline nano-delivery systems have been developed and reported to effectively circumvent MDR both in vitro and in vivo, and some of these systems have even advanced to clinical trials, such as the HPMA-doxorubicin (HPMA-DOX) conjugate. Doxil, a DOX PEGylated liposome formulation, was developed and approved by FDA in 1995. Unfortunately, this formulation does not address the MDR problem. In this comprehensive review, more than ten types of developed anthracycline nano-delivery systems to overcome MDR and their proposed mechanisms are covered and discussed, including liposomes; polymeric micelles, conjugate and nanoparticles; peptide/protein conjugates; solid-lipid, magnetic, gold, silica, and cyclodextrin nanoparticles; and carbon nanotubes.

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Keywords
Anthracyclines; Nanoparticles; Multi-drug resistance
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Anthracycline nano-delivery systems to overcome multiple drug resistance: A comprehensive review
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 8, Issue 3, June 2013, Pages 313–331
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us