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Turning a frown upside down: Exploiting nanoparticle toxicity for anticancer therapy

Paper ID Volume ID Publish Year Pages File Format Full-Text
32138 44904 2013 5 PDF Available
Title
Turning a frown upside down: Exploiting nanoparticle toxicity for anticancer therapy
Abstract

The use of nanosized materials is rapidly increasing, both in technological applications for daily use and in biomedical research. The use of these materials, especially for biomedical purposes is however still limited as the potential toxicity of nanomaterials warrants a lot of caution. The generation of a lot of toxicological data concerning nanomaterials sometimes creates a negative perception on their use. However, not all nanomaterials are the same and our understanding of how toxicity exerts itself and ways of how to control it for various particles is increasing. This control also offers us the possibility to exploit nanoparticle toxicity in a targeted manner, by means of selective autophagy induction or leaching of metal ions as a novel anticancer therapy. This manuscript provides an overview of work done on these topics, important achievements and key issues that need to be resolved to mature this novel scientific discipline.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (103 K)Download as PowerPoint slideHighlights► The cell type-dependent toxicity of nanomaterials is described. ► Two mechanisms by which nanoparticles exert cancer-specific toxicity are discussed. ► Suggestions are made on how to further exploit the intrinsic nanoparticle toxicity as anticancer therapy.

Keywords
Nanoparticles; Nanotoxicology; Cancer therapy; Autophagy; Particle degradation; Quantum dot; Zinc oxide
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Turning a frown upside down: Exploiting nanoparticle toxicity for anticancer therapy
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 8, Issue 2, April 2013, Pages 121–125
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us