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Super-hydrophilic zwitterionic poly(carboxybetaine) and amphiphilic non-ionic poly(ethylene glycol) for stealth nanoparticles

Paper ID Volume ID Publish Year Pages File Format Full-Text
32186 44908 2012 10 PDF Available
Title
Super-hydrophilic zwitterionic poly(carboxybetaine) and amphiphilic non-ionic poly(ethylene glycol) for stealth nanoparticles
Abstract

SummaryThis review compares two types of non-fouling polymers, the widely used non-ionic poly(ethylene glycol) (PEG) and the recently established zwitterionic poly(carboxybetaine) (PCB), for their use in creating stealth nanoparticles (NPs) for drug delivery and protein protection. While both types of polymers exhibit reasonable non-fouling properties, such as good protein and colloidal stability and extended blood circulation time in vivo, amphiphilic PEG has negative effects on proteins and NPs due to its hydrophobic nature, including reduced protein bioactivity, instability of assembled NPs, and lipid bilayer destabilization. These problems can be overcome by super-hydrophilic PCB.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (141 K)Download as PowerPoint slideHighlights► We compare non-ionic poly (ethylene glycol) (PEG) with zwitterionic poly(carboxybetaine) (PCB) in creating stealth nanoparticles. ► Both polymers exhibit good non-fouling properties due to strong hydration. ► Amphiphilic PEG has negative effects on proteins and nanoparticles due to its hydrophobic nature. ► PCB overcomes these problems due to its super-hydrophilic nature.

Keywords
Polyethylene glycol; Zwitterions; Non-fouling; Protein conjugation; Liposome; Drug delivery
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Super-hydrophilic zwitterionic poly(carboxybetaine) and amphiphilic non-ionic poly(ethylene glycol) for stealth nanoparticles
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 7, Issue 5, October 2012, Pages 404–413
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us