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Biodegradable polymeric micelles for targeted and controlled anticancer drug delivery: Promises, progress and prospects

Paper ID Volume ID Publish Year Pages File Format Full-Text
32190 44908 2012 14 PDF Available
Title
Biodegradable polymeric micelles for targeted and controlled anticancer drug delivery: Promises, progress and prospects
Abstract

SummaryBiodegradable polymeric micelles have emerged as one of the most promising platforms for targeted and controlled anticancer drug delivery due to their excellent biocompatibility, prolonged circulation time, enhanced accumulation in tumor, and in vivo degradability. Notably, several micellar anticancer drugs, with clear advantages of decreased side effects and improved drug tolerance, have advanced to different phases of clinical trials. The therapeutic outcomes are, however, far from optimal, due to issues of low in vivo stability, poor tumor penetration, inefficient cellular uptake, slow intracellular drug release, etc. This review highlights recent developments in functional biodegradable micelles for safe and efficient cancer chemotherapy.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (312 K)Download as PowerPoint slideHighlights► Overviews progress of biodegradable micellar drugs for clinical cancer treatments. ► Evaluates approaches to address the in vivo stability and drug release dilemma. ► Highlights strategies to achieve efficient tumor penetration and cell uptake. ► Gives personal perspectives on future development of micellar anticancer drugs.

Keywords
Anticancer drugs; Biodegradable micelles; Controlled drug release; Targeted delivery; Cancer therapy
First Page Preview
Biodegradable polymeric micelles for targeted and controlled anticancer drug delivery: Promises, progress and prospects
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 7, Issue 5, October 2012, Pages 467–480
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering