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In vivo modulation of dendritic cells by engineered materials: Towards new cancer vaccines

Paper ID Volume ID Publish Year Pages File Format Full-Text
32210 44910 2011 12 PDF Available
Title
In vivo modulation of dendritic cells by engineered materials: Towards new cancer vaccines
Abstract

SummaryTherapeutic cancer vaccines are emerging as novel and potent approaches to treat cancer. These vaccines enhance the body's immune response to cancerous cells, and dendritic cells (DCs), an initiator of adaptive immunity, are a key cell type targeted by these strategies. Current DC-based cancer vaccines are based on ex vivo manipulation of the cells following their isolation from the patient, followed by reintroduction to the patient, but this approach has many limitations in practical cancer treatment. However, recent progress in materials science has allowed the design and fabrication of physically and chemically functionalized materials platforms that can specifically target DCs in the body. These materials, through their in vivo modulation of DCs, have tremendous potentials as new cancer therapies. Nanoparticles, which are several orders of magnitude smaller than DCs, can efficiently deliver antigen and danger signals to these cells through passive or active targeting. Three-dimensional biomaterials, with sizes several orders of magnitude larger than DCs, create microenvironments that allow the effective recruitment and programming of these cells, and can be used as local depots of nanoparticles targeting resident DCs. Both material strategies have shown potential in promoting antigen-specific T cell responses of magnitudes relevant to treating cancer.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (180 K)Download as PowerPoint slideHighlights► Therapeutic cancer vaccines are emerging as novel and potent approaches to treat cancer. ► Current dendritic cell (DC)-based cancer vaccines have many limitations for practical cancer treatment. ► In vivo modulation of DCs using nanoparticles and three-dimensional biomaterials for therapeutic cancer vaccine was highlighted. ► Both material strategies have shown potential in promoting antigen-specific T cell responses of magnitudes relevant to treating cancer.

Keywords
Cytotoxic T lymphocytes; Dendritic cells; Hydrogels; Immunotherapy; Nanoparticles; Porous scaffolds
First Page Preview
In vivo modulation of dendritic cells by engineered materials: Towards new cancer vaccines
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 6, Issue 5, October 2011, Pages 466–477
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering