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Emerging nanomaterials for targeting subcellular organelles

Paper ID Volume ID Publish Year Pages File Format Full-Text
32211 44910 2011 15 PDF Available
Title
Emerging nanomaterials for targeting subcellular organelles
Abstract

SummaryOver the past decade, research interest in the application of biomedical nanotechnology to the diagnosis and treatment of disease has grown significantly, and physiological barriers to nanoparticle delivery may now be rationally overcome. Subcellular targeting is defined as engineered nanoparticle intracellular interactions, processing, and trafficking, and is a rapidly developing frontier of biomedical innovation. The potential clinical impact of nanoparticle subcellular targeting may be appreciated when considering the promise of effective gene therapies, molecular imaging devices, and treatments for organelle-specific diseases. In this review, we discuss recent innovations in the materials, ligands, and methods employed in designing subcellular nanotechnology, from cellular internalization methods and endosomal escape to recent approaches used to target the nucleus, mitochondria, endoplasmic reticulum, Golgi apparatus, as well as other organelles and intracellular events.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (202 K)Download as PowerPoint slideHighlights► Targeting cellular internalization mechanisms aids localization of nanoparticles. ► Endosomal escape is a critical step in effective delivery via endocytosis. ► Direct translocation across cellular membranes facilitates cytosolic access. ► Organelle-specific targeting has been demonstrated using various nanomaterials. ► Subcellular targeting remains an area with vast potential to advance nanomedicine.

Keywords
Nucleus; Mitochondria; Endoplasmic reticulum; Golgi apparatus; Nanoparticles; Controlled release; Targeted therapy
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 6, Issue 5, October 2011, Pages 478–492
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us