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Supramolecular nanostructures designed for high cargo loading capacity and kinetic stability

Paper ID Volume ID Publish Year Pages File Format Full-Text
32244 44914 2010 9 PDF Available
Title
Supramolecular nanostructures designed for high cargo loading capacity and kinetic stability
Abstract

SummaryBiodegradable triblock copolymers of PEG, poly(ethyl carbonate) and acid-functional polycarbonate with precisely controlled molecular weight and well-defined structure were synthesized via organocatalytic living ring opening polymerization, and self-assembled into nanostructures with narrow size distribution. These nanostructures demonstrated exceptionally high loading capacity of an amine-containing cargo (i.e. doxorubicin, an anticancer drug) due to acid–base ionic interaction between the cargo and the polymer. To further fine-tune critical properties of drug-loaded micelles, a urea-containing polycarbonate was combined with an acid-functional polycarbonate to form mixed micelles stabilized by hydrogen bonding interactions. The mixed micelles provided greater kinetic stability, nanosize with narrow size distribution and high cargo loading capacity. These nanostructures can be used as carriers to deliver a variety of anticancer drugs that contain amine functional groups.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (132 K)Download as PowerPoint slideResearch highlights▶ Acid-functional micelles have nanosize and great loading capacity for DOX. ▶ Acid/urea mixed micelles fine-tune size, kinetic stability and drug loading level. ▶ A platform is developed for delivery of anticancer drugs containing amine groups.

Keywords
Functional polycarbonate; Block copolymer; Self-assembly; Nanostructures; Mixed micelles; Drug delivery
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Supramolecular nanostructures designed for high cargo loading capacity and kinetic stability
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 5, Issue 6, December 2010, Pages 515–523
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us