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Enhancing cell therapies from the outside in: Cell surface engineering using synthetic nanomaterials

Paper ID Volume ID Publish Year Pages File Format Full-Text
32259 44915 2011 17 PDF Available
Title
Enhancing cell therapies from the outside in: Cell surface engineering using synthetic nanomaterials
Abstract

SummaryTherapeutic treatments based on the injection of living cells are in clinical use and preclinical development for diseases ranging from cancer to cardiovascular disease to diabetes. To enhance the function of therapeutic cells, a variety of chemical and materials science strategies are being developed that engineer the surface of therapeutic cells with new molecules, artificial receptors, and multifunctional nanomaterials, synthetically endowing donor cells with new properties and functions. These approaches offer a powerful complement to traditional genetic engineering strategies for enhancing the function of living cells.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (201 K)Download as PowerPoint slideHighlights► In this review, we will first summarize key methodologies used to manipulate the surface of living mammalian cells with synthetic material. ► We will then discuss the main challenges to overcome to stably modify cell surfaces and we will highlight how these cell modifications can be applied to enhance the therapeutic potential of cell products in clinic. ► Finally, we will outline future trends and perspectives of this relatively new and fast-developing discipline.

Keywords
Cell therapy; Cell surface bioengineering; Adoptive T cell therapy; Nanoparticles
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 6, Issue 3, June 2011, Pages 309–325
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us