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Silicon nanowires-based highly-efficient SERS-active platform for ultrasensitive DNA detection

Paper ID Volume ID Publish Year Pages File Format Full-Text
32291 44920 2011 9 PDF Available
Title
Silicon nanowires-based highly-efficient SERS-active platform for ultrasensitive DNA detection
Abstract

SummaryA nanostructured complex, silicon nanowires (SiNWs) coated with in situ grown AgNPs (SiNWs@AgNPs), is developed as a well-defined surface-enhanced Raman Scattering (SERS)-active platform for ultrasensitive DNA detection. Such SiNWs@AgNPs nanostructure possesses an extremely high SERS enhancement factor of ∼1010. We design a DNA sensor based on the nanostructure via immobilization of capture probe DNA at the surface of AgNPs, and a sandwich strategy for the detection of target DNA that brings a reporter probe labeled with a dye to the proximity of the surface, leading to high SERS signals. This silicon nanostructure-based biosensor platform can detect a remarkably low DNA concentration at ∼1 fM, which is comparable to the lowest DNA concentration ever detected via SERS. We expect this highly sensitive and robust SiNWs-based SERS platform may serve as a practical and powerful tool for biomolecular sensing and biomedical analysis.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (297 K)Download as PowerPoint slideResearch highlights► A new silicon nanowires (SiNWs)-based SERS-active platform is developed for ultrahigh-sensitive DNA detection. ► This SiNWs-based platform possesses an exceptionally high SERS enhancement factor (∼1010), which is developed to a high-performance DNA biosensor. ► This silicon-based biosensor can readily detect a remarkably low DNA concentration at 1 fM, which is the lowest DNA concentration ever detected via SERS.

Keywords
Silicon nanowires; SERS; Hot spot; DNA detection
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Silicon nanowires-based highly-efficient SERS-active platform for ultrasensitive DNA detection
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 6, Issue 2, April 2011, Pages 122–130
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us