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Silicon nanowire field-effect transistor-based biosensors for biomedical diagnosis and cellular recording investigation

Paper ID Volume ID Publish Year Pages File Format Full-Text
32292 44920 2011 24 PDF Available
Title
Silicon nanowire field-effect transistor-based biosensors for biomedical diagnosis and cellular recording investigation
Abstract

SummarySilicon nanowire field-effect transistors (SiNW-FETs) have recently drawn tremendous attention as a promising tool in biosensor design because of their ultrasensitivity, selectivity, and label-free and real-time detection capabilities. Here, we review the recently published literature that describes the device fabrication and biomedical applications of SiNW-FET sensors. For practical uses, SiNW-FETs can be delicately designed to be a reusable device via a reversible surface functionalization method. In the fields of biological research, SiNW-FETs are employed in the detections of proteins, DNA sequences, small molecules, cancer biomarkers, and viruses. The methods by which the SiNW-FET devices were integrated with these representative examples and advanced to virus infection diagnosis or early cancer detection will be discussed. In addition, the utilization of SiNW-FETs in recording the physiological responses from cells or tissues will also be reviewed. Finally, the novel design of a three dimensional (3D) nano-FET probe with kinked SiNWs for recording intracellular signals will be highlighted in this review.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (174 K)Download as PowerPoint slideResearch highlights► Silicon nanowires configured field-effect transistors were used as a biosensor. ► To investigate protein–protein interaction and DNA hybridization. ► For viral infection monitoring, early cancer detection, and biomarker detection. ► To monitor electrical and transmitter signals from living cells. ► Synthesize a 3D-localized bioprobe to record intracellular potentials.

Keywords
AFM, atomic force microscopy; ATP, adenosine triphosphate; CA, carbohydrate antigen; CaM, calmodulin; CEA, carcinoembryonic antigen; CgA, chromogranin A; CNT, carbon nanotube; CVD, chemical vapor deposition; DNA, deoxyribonucleic acid; EDTA, ethylenediami
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Silicon nanowire field-effect transistor-based biosensors for biomedical diagnosis and cellular recording investigation
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 6, Issue 2, April 2011, Pages 131–154
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us