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Design of polymeric microparticles for pH-responsive and time-sustained drug release

Paper ID Volume ID Publish Year Pages File Format Full-Text
3230 159 2013 10 PDF Available
Title
Design of polymeric microparticles for pH-responsive and time-sustained drug release
Abstract

•Spray drying of uniform enteric microparticles from aqueous based dispersions.•Drying temperature dominated particle morphologies.•Tuning pH responsiveness and drug release kinetics of the microparticles by incorporating network forming materials.•Design of microstructural properties and drug release kinetics by controlling the colloidal interactions among different components.

We described the design of uniform microencapsulates with almost 100% encapsulation efficiency, synthesized without organic solvents, via microfluidic spray drying of water-based dispersions of pH-responsive methacrylic acid polymers (Eudragit® L 30D-55). The effects of incorporating water-based network-forming materials in the formulations on pH-responsiveness and controlled release patterns of enteric microparticles were observed. Acid hydrolysed tetraethoxysilane (TEOS) was used to form an interpenetrating, rigid framework of silica, whereas Eudragit® NE (a copolymer based on ethyl acrylate and methyl methacrylate) was added to produce a more flexible polymeric network. The spray-dried microparticles generally displayed crumbled or buckled morphologies dependent on drying temperatures, due to large hydrodynamic sizes of solutes in feed dispersions. The drug release kinetics of microparticles were sensitive to the type and the added amount of network-forming materials, due to different colloidal interactions between Eudragit® L and either silica or the copolymer. This study demonstrated a strategy to design enteric microparticles with different microstructural properties and drug release behaviours through understanding of colloidal interactions between constituents of matrix materials.

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Keywords
Uniform microencapsulates; Microfluidic-jet spray drying; pH-responsive release; Time-sustained release; Colloidal interactions; Microstructural design
First Page Preview
Design of polymeric microparticles for pH-responsive and time-sustained drug release
Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 81, 15 December 2013, Pages 177–186
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering