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Poly(carboxybetaine) nanomaterials enable long circulation and prevent polymer-specific antibody production

Paper ID Volume ID Publish Year Pages File Format Full-Text
32303 44921 2014 7 PDF Available
Title
Poly(carboxybetaine) nanomaterials enable long circulation and prevent polymer-specific antibody production
Abstract

•Poly(carboxybetaine) nanomaterials do not induce antibody production.•Poly(carboxybetaine) nanomaterials have a prolonged circulation half-life of 56 h.•Poly(carboxybetaine) nanomaterials have similar half-life between two injections.•PEG-coated counterparts suffered from accelerated blood clearance.

SummaryPoly(ethylene glycol) (PEG) has been incorporated into nanoparticles (NPs) to improve circulation time from systemic circulation for decades with limited success. Recent studies have shown that PEG induces the production of PEG-specific antibodies after repeated injections. Here, we demonstrate zwitterionic poly(carboxybetaine) (PCB)-based nanomaterials with no production of polymer-specific antibodies, while PEG-coated NPs generated PEG-specific antibodies. Furthermore, PCB-coated NPs exhibited prolonged circulation time and showed little change between the first and second doses (t1/2 = 55.8 and 55.6 h), with no accelerated blood clearance suffered by PEG-coated NPs (t1/2 drops from 8.7 to 5.2 h). These findings are significant advances toward solving the long-standing clinical challenge of developing nanomaterials that are able to resist both immune response and immediate bodily clearance.

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Keywords
Nanomaterials; Free antibody production; Long-circulating; Polymers
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Poly(carboxybetaine) nanomaterials enable long circulation and prevent polymer-specific antibody production
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 9, Issue 1, February 2014, Pages 10–16
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us