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Integrated functional nanocolloids covered with artificial cell membranes for biomedical applications

Paper ID Volume ID Publish Year Pages File Format Full-Text
32351 44923 2011 14 PDF Available
Title
Integrated functional nanocolloids covered with artificial cell membranes for biomedical applications
Abstract

SummaryThe functionality of nanocolloids used in biomedical applications are subject to strong interference arising from significant interactions with biological components such as proteins and cells. Among the known examples of surface treatment of nanocolloids, the construction of an artificial cell membrane structure based on phospholipid polymers has proven effective in preventing the occurrence of biological reactions at the surface. Furthermore, certain bioactive molecules can be immobilized on the surface of the phospholipid polymer platform to generate bioaffinity for other biomolecules. This review describes preparation and characterization of integrated functional nanocolloids covered by artificial cell membrane structures and their performance in biomedical applications.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (147 K)Download as PowerPoint slideResearch highlights▶ Nanocolloids covered with phosphorylcholine (PC) groups can be used for biomedical applications. ▶ The use of amphiphilic phospholipid polymers is effective as nanocolloids. ▶ Bioactive molecules-immobilized the PC platform are applied to targeted gene and drug delivery. ▶ Cellular uptake of quantum dots can be controlled by functionalization with phospholipid polymer.

Keywords
Nanocolloids; Artificial cell membrane; Surface modification; 2-Methacryloyloxyethyl phosphorylcholine (MPC) polymer; Protein adsorption; Cell adhesion
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 6, Issue 1, February 2011, Pages 61–74
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us