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Self-assembled and nanostructured hydrogels for drug delivery and tissue engineering

Paper ID Volume ID Publish Year Pages File Format Full-Text
32379 44925 2009 9 PDF Available
Title
Self-assembled and nanostructured hydrogels for drug delivery and tissue engineering
Abstract

SummaryWater soluble polymers can be tailored to exhibit sol–gel transition behaviors in response to external stimuli such as temperature and pH. Amphiphilic block copolymers and peptide oligomers with specific sequences can go through self-assembly to form a nanostructured hydrogel under physiological conditions. A wide range of sol–gel transition hydrogels can be synthesized by introducing physically crosslinkable junctions such as hydrophobic groups, pH-sensitive moieties, and stereocomplexed crystallizable domains in the polymer structure. Furthermore, the in situ forming and injectable hydrogels can also be functionalized with bioactive molecules such as heparin, cell adhesive peptides, and hyaluronic acid, to provide sustained release of therapeutic proteins or support the growth and function of cells. Various sol–gel transition, biodegradable, and biocompatible hydrogels show great potentials as injectable materials in drug delivery and tissue engineering.

Keywords
Hydrogel; Injectable; In situ formation; Drug delivery; Tissue engineering
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Self-assembled and nanostructured hydrogels for drug delivery and tissue engineering
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 4, Issue 5, October 2009, Pages 429–437
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us