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Polymer- and lipid-based nanoparticle therapeutics for the treatment of liver diseases

Paper ID Volume ID Publish Year Pages File Format Full-Text
32405 44927 2010 17 PDF Available
Title
Polymer- and lipid-based nanoparticle therapeutics for the treatment of liver diseases
Abstract

SummaryLiver diseases, particularly hepatitis B virus infections, liver cirrhosis and hepatocellular carcinoma continue to pose a significant health challenge worldwide due to the dire lack of curative treatment options besides liver resection and transplantation. Nanoparticle therapeutics, comprising of drugs, nucleic acids or proteins in association with a carrier, have emerged as safe and efficient systems in the treatment of the respective liver diseases. This review describes targeting strategies employed in relation to liver anatomy and disease etiologies, summarizes recent advances in the field and discusses the challenges and future perspectives for the effective treatment of liver diseases using polymer- and lipid-based nanoparticle therapeutics.

Keywords
Drug delivery; Nanoparticles; Liver targeting; Hepatitis B virus infection; Liver fibrosis; Hepatocellular carcinoma (HCC)
First Page Preview
Polymer- and lipid-based nanoparticle therapeutics for the treatment of liver diseases
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 5, Issue 4, August 2010, Pages 296–312
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering