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Emerging trends in macromolecular antimicrobials to fight multi-drug-resistant infections

Paper ID Volume ID Publish Year Pages File Format Full-Text
32454 44930 2012 22 PDF Available
Title
Emerging trends in macromolecular antimicrobials to fight multi-drug-resistant infections
Abstract

SummarySynthetic macromolecular antimicrobials are a highly promising class of therapeutics with immense potential for combating multidrug resistant microbes. In contrast to conventional small molecule antibiotics, macromolecular antimicrobial agents mediate physical disruption of microbial cell membranes, thereby reducing the likelihood of pathogens developing resistance. This review highlights recent advances in the development of synthetic membrane-active macromolecules with focus on peptides and polymers that adopt well-defined nanostructures or conformations (e.g. secondary helical structures, self-assembled nanoparticles, and hyperbranched structures). An overview of proposed antimicrobial mechanisms, followed by a description of structural parameters which govern selectivity of macromolecular agents for microbial cells over mammalian cells is provided. Pertinent examples of well-defined nanostructure-based macromolecular antimicrobial agents are discussed. Moreover, challenges and future perspectives in the development of safe and effective macromolecular antimicrobial agents for eventual clinical applications are presented.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (324 K)Download as PowerPoint slideHighlights► Recent advances in synthetic membrane-active macromolecule antimicrobials. ► Structural parameters that govern activity and selectivity of macromolecules. ► Effects of nanostructure, helical conformation, and hyperbrancing. ► Outlook on the development of safe and effective macromolecular antimicrobials.

Keywords
Antimicrobial; Macromolecule; Polymer; Self-assembly; Peptide; Dendrimer
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Emerging trends in macromolecular antimicrobials to fight multi-drug-resistant infections
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 7, Issue 3, June 2012, Pages 201–222
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us