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Stimuli-responsive polymers for the targeted delivery of paclitaxel to hepatocytes

Paper ID Volume ID Publish Year Pages File Format Full-Text
32506 44933 2010 6 PDF Available
Title
Stimuli-responsive polymers for the targeted delivery of paclitaxel to hepatocytes
Abstract

SummaryThis study presents a targeted and stimuli-responsive drug delivery system to increase the therapeutic window of chemotherapeutic agents. Galactose was expressed on an amphiphilic, temperature- and pH-sensitive copolymer of N-isopropylacrylamide, N,N-dimethylacrylamide and 10-undecenoic acid. The polymer would self-assemble in aqueous medium, and was used to encapsulate paclitaxel. Various synthesis parameters were examined to achieve polymers that provide high drug loading and rapid release in a temperature- and pH-responsive manner. In the target hepatocyte cell line, the stimuli-responsive, galactose-expressing particles were significantly more toxic than the non-stimuli-responsive particles as well as the non-targeted particles.

Keywords
Galactose-targeting; pH-sensitive; Thermosensitive; Paclitaxel; Hepatocytes
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Stimuli-responsive polymers for the targeted delivery of paclitaxel to hepatocytes
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 5, Issue 1, February 2010, Pages 9–14
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us