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Use of agar as carrier in solid-state fermentation for Monacolin K production by Monascus: A novel method for direct determination of biomass and accurate comparison with submerged fermentation

Paper ID Volume ID Publish Year Pages File Format Full-Text
3259 161 2013 4 PDF Available
Title
Use of agar as carrier in solid-state fermentation for Monacolin K production by Monascus: A novel method for direct determination of biomass and accurate comparison with submerged fermentation
Abstract

•A novel solid-state fermentation process by using agar as carrier was developed.•The novel system was successfully used for production of Monacolin K by Monascus.•Monacolin K production reached 2047 mg/L in SSF, 4.47 times as much as that of SmF.•It was feasible for direct determination of biomass and comparison with SmF.

For the first time, a novel solid-state fermentation (SSF) process by using agar as carrier was developed and it was feasible for direct determination of fungal biomass and accurate comparison with submerged fermentation (SmF). Specifically, this novel system was successfully applied for the production of Monacolin K by Monascus purpureus. Results showed that the optimal agar concentration, particle size and glycerol concentration were 4%, 4 mm × 4 mm × 4 mm and 18%, respectively, in which the Monacolin K production reached 2047.03 mg/L, 4.47 times as much as that of SmF. The comparative time course study showed that the biomass accumulation, MK biosynthesis and glycerol consumption in SSF were more rapid than that of the SmF.

Graphical abstractTime course of microbial growth and Monacolin K synthesis by Monascus purpureus during solid-state fermentation and submerged fermentation.Figure optionsDownload full-size imageDownload as PowerPoint slide

Keywords
Monascus purpureus; Monacolin K; Solid-state fermentation; Submerged culture; Bioprocess design; Optimization
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Use of agar as carrier in solid-state fermentation for Monacolin K production by Monascus: A novel method for direct determination of biomass and accurate comparison with submerged fermentation
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 80, 15 November 2013, Pages 10–13
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us