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Integrated microfluidic reactors

Paper ID Volume ID Publish Year Pages File Format Full-Text
32649 44938 2009 12 PDF Available
Title
Integrated microfluidic reactors
Abstract

SummaryMicrofluidic reactors exhibit intrinsic advantages of reduced chemical consumption, safety, high surface-area-to-volume ratios, and improved control over mass and heat transfer superior to the macroscopic reaction setting. In contract to a continuous-flow microfluidic system composed of only a microchannel network, an integrated microfluidic system represents a scalable integration of a microchannel network with functional microfluidic modules, thus enabling the execution and automation of complicated chemical reactions in a single device. In this review, we summarize recent progresses on the development of integrated microfluidics-based chemical reactors for (i) parallel screening of in situ click chemistry libraries, (ii) multistep synthesis of radiolabeled imaging probes for positron emission tomography (PET), (iii) sequential preparation of individually addressable conducting polymer nanowire (CPNW), and (iv) solid-phase synthesis of DNA oligonucleotides. These proof-of-principle demonstrations validate the feasibility and set a solid foundation for exploring a broad application of the integrated microfluidic system.

Keywords
Integrated microfluidics; Chemical screening; In situ click chemistry; Sequential synthesis; Positron emission tomography probes; Oligonucleotide synthesis; Conducting polymer nanowires
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 4, Issue 6, December 2009, Pages 470–481
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us