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Coupling use of surfactant and in situ extractant for enhanced production of Antrodin C by submerged fermentation of Antrodia camphorata

Paper ID Volume ID Publish Year Pages File Format Full-Text
3284 162 2013 6 PDF Available
Title
Coupling use of surfactant and in situ extractant for enhanced production of Antrodin C by submerged fermentation of Antrodia camphorata
Abstract

•Effects of different surfactants and in situ extractants were investigated.•The optimal surfactant and extractant were Tween-80 and soybean oil, respectively.•The strategy was applied for enhanced Antrodin C production by SmF of Antrodia camphorata.•Under the optimum conditions, the Antrodin C production was increased by 3.6 times.•The biphasic system was firstly used for enhanced medicinal fungi metabolites.

In this study, a biphasic fermentation system coupling use of surfactant and in situ extractant was established to enhance Antrodin C production in submerged fermentation of Antrodia camphorata. Effects of several crucial factors such as the selection, concentration and addition time of surfactants and in situ extractants on the mycelial growth and production of Antrodin C were systematically studied. Results showed that the optimal surfactant and extractant were Tween-80 and soybean oil, respectively. The maximum production of Antrodin C (247.09 ± 0.97 mg/L) was obtained when 0.1% (w/v) Tween-80 (as surfactant) and 10% (v/v) soybean oil (as in situ extractant) both supplied at the logarithmic growth phase of fermentation (the 72th h and the 96th h, respectively), corresponding to 3.6 times significant increase compared with that of the control (53.23 ± 0.86 mg/L).

Keywords
Antrodia camphorata; Antrodin C; Biosynthesis; Bioprocess design; Submerged culture; Integrated processing
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Coupling use of surfactant and in situ extractant for enhanced production of Antrodin C by submerged fermentation of Antrodia camphorata
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 79, 15 October 2013, Pages 194–199
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us